Hypophysitis Secondary to Cytotoxic T-Lymphocyte–Associated Protein 4 Blockade
نویسندگان
چکیده
منابع مشابه
Hypophysitis Secondary to Cytotoxic T-Lymphocyte-Associated Protein 4 Blockade: Insights into Pathogenesis from an Autopsy Series.
Hypophysitis that develops in cancer patients treated with monoclonal antibodies blocking cytotoxic T-lymphocyte-associated protein 4 (CTLA-4; an inhibitory molecule classically expressed on T cells) is now reported at an incidence of approximately 10%. Its pathogenesis is unknown, in part because no pathologic examination of the pituitary gland has been reported to date. We analyzed at autopsy...
متن کاملTransient hypophysitis after cytotoxic T lymphocyte-associated antigen 4 (CTLA4) blockade.
C T LYMPHOCYTE-associated antigen 4 (CTLA4) blockade using the human anti-CTLA4 monoclonal antibody CP-675,206 has antitumor activity in melanoma (1). Blockade of CTLA4 binding to its B7 ligands results in disruption of peripheral immune tolerance and enhanced T cell activation (2), which can cause secondary autoimmune endocrinopathies, including hypophysitis and thyroiditis (1, 3, 4). We herei...
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www.expert-reviews.com ISSN 1744-6651 © 2009 Expert Reviews Ltd 10.1586/EEM.09.37 General features of autoimmune hypophysitis Autoimmune (lymphocytic) hypophysitis (AH), is a chronic inflammation of the pituitary gland caused or accompanied by pituitary autoimmunity [1,2]. It can be classified etiologically into two groups: primary and secondary hypophysitis. Primary hypophysitis is, by definit...
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The relationship between cancer and the immune system is complex and provides unique therapeutic opportunities. Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a regulatory molecule that suppresses T cell effector function following initial activation by costimulatory signals. Fully human monoclonal antibodies targeting CTLA-4 have been shown to increase T cell function and antitumor responses in ...
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Introduction The immune system is an important defense against the development and progression of cancer (1). Historically, there has been a waxing and waning enthusiasm for immune therapies to treat cancer due to limited efficacy. Immunotherapies, such as IL-2 and adoptive transfer of autologous tumor-infiltrating lymphocytes, can induce durable tumor responses in a subset of patients, leading...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2016
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2016.08.020